COMPARATIVE STUDY OF SHORT TERM OUTCOME OF PATIENTS WITH KNEE OSTEOARTHRITIS TREATED WITH PLATELET RICH PLASMA AND STEROIDS (TRIAMCINOLONE). A PROSPECTIVE, RANDOMIZED, DOUBLE BLIND STUDY.

Dr. Akshay Patel; Dr. Vinod Gautam; Dr.Pinakin Vora

Volume : VIII, Issue : II, February - 2019

COMPARATIVE STUDY OF SHORT TERM OUTCOME OF PATIENTS WITH KNEE OSTEOARTHRITIS TREATED WITH PLATELET RICH PLASMA AND STEROIDS (TRIAMCINOLONE). A PROSPECTIVE, RANDOMIZED, DOUBLE BLIND STUDY.

Dr. Akshay Patel, Dr. Vinod Gautam, Dr. Pinakin Vora

Abstract :

Background and Objectives: This study aims to assess whether intraarticlar injection of platelet rich plasma (PRP) and triamcenolone (steroid) are effective treatment for knee osteoarthritis, and compare both of them in terms of pain, knee joint stiffness and function and side effects. Methodology: This prospective study was carried out at the Department of orthopedics, Sir T hospital, Bhavnagar. In this study, around 60 patients (29 males, 31 females; mean age 51.3 years range; 40 to 70 years) with osteoarthritis knee (kellgran Lawrence grade 1-3) were included. Patients were randomized into two groups; one group including 30 patients received intraarticular PRP injection and other group including 30 patients received intraarticular steroid. The patients were evaluated using VAS score and WOMAC score before the treatment and at 1month, 2month and 6 month after the treatment. Results: In the PRP and steroid groups, when pretreatment VAS and WOMAC scores were compared with each other, there was no significant difference was seen, In PRP groups, VAS and WOMAC scores decreased significantly at 1st month, 2nd month and 6th month follow-up. In Steroid group, VAS and WOMAC scores decreased significantly at 1st month and 2nd month followup; however at 6th month follow-up, VAS and WOMAC scores were increased while no significant difference was found with baseline. When groups were compared at 6 month follow-up, VAS and WOMAC scores of PRP group were significantly lower than steroid group. Interpretation and Conclusion: In conclusion, our findings have shown that intraarticular PRP injections are more safe and effective treatment than intraarticular steroid in 6 months follow-up study. Treatment response obtained with corticosteroid injection has a shorter duration than PRP treatment.