Comparative Study of Effectiveness and Tolerability of S-Amlodipine and Amlodipine (Racemic) in the Treatment of Mild to Moderate Hypertension

Nisha Bharti; Sanjay Kumar; (Prof.) Sanjay Kumar; Pallavi Lohani

Volume : VIII, Issue : VII, July - 2019

Comparative Study of Effectiveness and Tolerability of S-Amlodipine and Amlodipine (Racemic) in the Treatment of Mild to Moderate Hypertension

Nisha Bharti, Sanjay Kumar, Prof. Sanjay Kumar, Pallavi Lohani

Abstract :

Objective- To compare the effectiveness and tolerability of S-Amlodipine 2.5 mg and Amlodipine(Racemic) 5 mg in the treatment of mild to moderate hypertension. Materials and methods - This prospective, randomized, open, comparative, observational study was conducted in the department of pharmacology, NMCH, Patna. This was 8 weeks study between 15 Jan 2019 to 15 March 2019 in 100 mild to moderate hypertensive patients (male 57 and female 43), age ranging between 30 to 70 years visiting outdoor, medicine department, NMCH, Patna.. Patients were randomly distributed into two groups of 50 each. Group A was given 2.5 mg S-Amlodipine and group B was given 5 mg amlodipine (racemic) for duration of 8 weeks. The average systolic and diastolic blood pressures in sitting position of both groups were taken at the start of study (baseline) and 8 weeks. Both the groups were compared and statistical analysis was done by paired student �t� test. Results - The change in systolic blood pressure (SBP) in Group-A is from 163.84� 10.38 to 142.39 � 8.42 mmHg and in Group-B from 163.64 � 10.92 to 142.63 � 7.82 mmHg. The change in diastolic blood pressure (DBP) in Group-A is from 100.20 � 7.46 to 86.49 � 6.34 mmHg and in Group-B from 100.34 � 7.28 to 86.88 � 6.26mmHg. Changes in both the groups are statistically significant with p-value < 0.0001. The difference between Group-A and Group-B for reduction in blood pressures (for both systolic and diastolic) is not statistically significant. Incidence of pedal edema was significantly less in S-Amlodipine group. Conclusion - Present study clearly indicates S-Amlodipine 2.5 mg is as effective as racemic Amlodipine 5 mg in control of mild to moderate hypertension with better tolerability.