Comparative study of effectiveness and safety of Azilsartan and Candesartan cilexetil in patients with grade 1-2 essential hypertension in a tertiary care hospital

Indu Priyadarshini; Satish Kumar; Nadia Az Zahra

Volume : VIII, Issue : X, October - 2019

Comparative study of effectiveness and safety of Azilsartan and Candesartan cilexetil in patients with grade 1-2 essential hypertension in a tertiary care hospital

Indu Priyadarshini, Satish Kumar, Nadia Az Zahra

Abstract :

Introduction: - Hypertension is defined as either a sustained systolic blood pressure of greater than 140 mm Hg or a sustained diastolic blood pressure of greater than 90 mm Hg. . It can lead to coronary artery disease (CAD), heart failure, stroke, renal failure and other health problems. The angiotensin receptor blockers are effective antihypertensive agent with excellent tolerability profiles. The present study was designed to compare the clinical effectiveness and tolerability of Azilsartan 40 mg OD with Candesartan 12mg OD in patients with grade 1-2 essential hypertension. Materials and methods: - The present study was a randomized study in 80 eligible patients comp� the effectiveness and safety of Azilsartan 40 mg with candesartan 12mg in patients with grade 1 or 2 essential hypertension. Result - Significantly greater reductions in the sitting DBP and SBP were recorded in the Azilsartan group in comparison with the candesartan group at 2 weeks, 4 weeks and 8 weeks. (P value<0.001). The most common adverse effect occurring in the patients in Azilsartan as well as in candesartan were nasopharyngitis, upper RTI and pharyngitis. Hypotension related adverse effects such as dizziness, syncope, vertigo was reported in both the drugs. Conclusion: - Azilsartan is more effective and safe blood pressure lowering drug as comparable to that of Candesartan