COMPARATIVE EVALUATION OF TRANEXAMIC ACID AND HEMOCOAGULASE ON BLOOD LOSS IN ORTHOPEDIC HIP SURGERIES.

Ankit singh; Deepesh Gupta

Volume : VIII, Issue : VIII, August - 2019

COMPARATIVE EVALUATION OF TRANEXAMIC ACID AND HEMOCOAGULASE ON BLOOD LOSS IN ORTHOPEDIC HIP SURGERIES.

Ankit Singh, Deepesh Gupta

Abstract :

Introduction: Major hip surgeries are often associated with significant blood loss. Aim of this clinical study, was to evaluate the efficacy of intravenous hemocoagulase, tranexamic acid in reducing perioperative blood loss and blood transfusion requirements in these surgeries. Material and Method: With approval of institutional ethics committee and written informed consent, a prospective, randomised study is undertaken on 60 patients from 16 to 60 years of age belonging to ASA physical status I and II, posted for elective lower limb surgery. These patients were randomly divided into two study groups of 30 patients each using �slip in the box� method for randomization. Group 1 (n=30) received 1gm IV tranexamic acid in normal saline to make a total volume of 500 ml, 10 minutes prior to incision. Group 2 (n=30) received 1 NIH of IV hemocoagulase in normal saline to make a total volume of 500 ml, 10 minutes prior to incision. The patients were intraoperatively monitored for hemodynamic parameters and blood loss and collection in the drain on postoperative day 1 was noted. The duration of surgery was noted. Postoperatively, Hb and Hct analysis and coagulation profile were done. Side effects and complications of drugs were also recorded. Results: Total perioperative blood loss in group 1 was 732.33 �82.39 ml and group 2 was 690.67 �70.86 ml which was not statistically significant. There was no statistically significant difference in percentage fall in Hb and hct between the two groups but statistically significant difference was noted within the groups between pre-op and values after 24 hrs. Conclusion: Hemocoagulase and tranexamic acid can markedly reduce blood loss and transfusion requirements in major hip and surgeries. No apparent adverse events were observed.