Comparative Evaluation of Timing of Dexmedetomidine Administration for Prevention of Sevoflurane Related Emergence Agitation in Pediatric Ophthalmic Surgery

Dr Shradhanand Kujur; Dr Boniface Hembrom

Volume : VII, Issue : VII, July - 2018

Comparative Evaluation of Timing of Dexmedetomidine Administration for Prevention of Sevoflurane Related Emergence Agitation in Pediatric Ophthalmic Surgery

Dr Shradhanand Kujur, Dr Boniface Hembrom

Abstract :

Introduction: The term �emergence agitation� has been used interchangeably with �emergence delirium� in the literature but there are differences in definitions and clinical presentations. Agitation, which is described as excessive motor activity, is a nonspecific symptom that incorporates discomfort, pain and anxiety¹. Delirium on the other hand, is an acute state of confusion accompanied by cognitive impairment including perceptual disturbances and hallucinations. Aims and Objectives :Our aim was toComparatively Evaluate the Timing of Dexmedetomidine Administration for Prevention of Sevoflurane Related Emergence Agitation in Pediatric Ophthalmic Surgery.Materials and Methods:Randomized control trial was done for comp�the Timing of Dexmedetomidine Administration for Prevention of Sevoflurane Related Emergence Agitation in Pediatric Ophthalmic Surgeryafter approval of Institutional ethical committee. 300 Patients were randomly assigned into two groups by computer generated random numbers for comparison. Group I received IV dexmedetomidine 0.5�g/kg 10 min. prior to induction (n=150) ,Group – II received IV dexmedetomidine 0.5�g/kg 5 min before the end of surgery (n=150).Template was generated in Excel Sheet and was analysed using SPSS version 20. Unpaired student t test was applied for comp� mean[quantitative data] and chi square test was applied for qualitative data.Paired t test was applied for intra-group comparison of the means of hemodynamic variables. The test was considered significant if p<0.05, at 95% confidence level. Results: The incidence and severity of EA were measured upon admission to the PACU. Severity of EA was measured with PAEDS scale. In Group I 7 (4.67%) patients severely suffered EA whereas in Group II 5 (3.34%) patients sevierly suffered EA.Better reduction was observed in Group II compare to Group I.Conclusion: Dexmedetomidine 0.5�g/kg IV administered 10 min prior to induction of GA and dexmedetomidine 0.5�g/kg IV administered 5 min before the end of surgery effectively reduce the incidence and severity of emergence agitation in children undergoing ophthalmic surgery.