Coeliac disease and Fanconi anemia: rare association in pediatric age group

M.ELBAZ; A. BOURRAHOUAT; J. ELHOUDZI

Volume : VIII, Issue : I, January - 2019

Coeliac disease and Fanconi anemia: rare association in pediatric age group

M. Elbaz, A. Bourrahouat, J. Elhoudzi

Abstract :

Introduction: The association of coeliac disease (CD) and aplastic anemia (AA) had been rarely described specially in pediatric group. This is the fifth report in the literature to date that suggests an association of AA with CD in the pediatric population. Case presentation: We report first case in Marrakesh, of a 11-year-old girl, followed for celiac disease since the age of 2 years. She was under a gluten free diet. She presented a persistent anemia, which revealed Fanconi disease with presence of chromosomal abnormalities on the karyotype. After a while, bone marrow aspiration showed acute myeloid leukemia type 0. Chemotherapy was done according to the AML-MA-2011 protocol. The patient died by overwhelming hemorrhagic syndrome after induction II. Discussion- Conclusion: All four pediatric cases reported with this potential association are from South East Asia but our case is the first from Africa. This association may be more frequent than previously. More studies are needed on this particular association, which has been largely under- estimated until now.