CLINICOPATHOLOGICAL CORRELATION OF POLYCYSTIC  OVARIAN SYNDROME AND INFERTILITY IN 100 INFERTILE FEMALE CASES

Sunita Poriya; Sonia Kundu; Bhetariya Bharat; Nandini J. Desai

Volume : VI, Issue : I, January - 2017

CLINICOPATHOLOGICAL CORRELATION OF POLYCYSTIC OVARIAN SYNDROME AND INFERTILITY IN 100 INFERTILE FEMALE CASES

Sunita Poriya, Sonia Kundu, Bhetariya Bharat, Nandini J. Desai

Abstract :

Infertility is considered as a matter of inequality and social injustice, along with a major health problem. Among the causes for female infertility, polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory infertility, being found in ∼75% of cases. It affects approximately 5-10% of women of reproductive age group. With the advancement in hormonal assessment techniques, endometrial biopsy and Ultrasonography, PCOS has shown a remarkable increase in its incidence in recent years. OBJECTIVES: To Diagnose the cases of PCOS by using triad of ultrasonography ,biochemical investigations like LH, FSH and Prolactin levels and endometrial biopsy and thus evaluating the correlation of PCOS and infertility and the preferred treatment line. MATERIAL AND METHODS: This was a study of 100 infertile females ( excluding the male factors) over a period of two years (2013-2015). Evaluation for PCOS was done using hormonal assay, ultrasonography and endometrial biopsy in a tertiary care hospital. RESULT: In our study, ovulatory defects were seen in 37 cases (37%) which constituted maximum number of cases in female infertility. PCOS constituted 18 cases (48.6%) of the ovulatory defects, maximum in the age group of 26-30 years ( 38.9%), among which 72.2% were of primary infertility type. LH:FSH ratio was more than 1.6 in 88.9% of the PCOS cases. Maximum PCOS cases were correlating to the histopathological finding of anovulatory phase of endometrium and more than 50% were correlating with ultrasonographic finding of PCOS ovary. CONCLUSION: PCOS was the most common cause of infertility among young females of new generation. Combination of change in life style modifications and treatment including clomiphene citrate can lead to better outcome.