Clinical utility of Biochemical markers on Osteoporosis in pre and postmenopausal women

Sankaralal.T; Rajasekaran.S; Prabhakar Reddy.E

Volume : IX, Issue : VII, July - 2020

Clinical utility of Biochemical markers on Osteoporosis in pre and postmenopausal women

Sankaralal. T, Rajasekaran. S, Prabhakar Reddy. E

Abstract :

The awareness of osteoporosis has grown worldwide in recent years. This silently progressing metabolicbone disease is widely prevalent in India, and osteoporotic fractures are a common cause of morbidity andmortality in adult Indian men and women. Rapid bone loss occurs in postmenopausal women due to hormonalfactors which lead to increased risk of fractures.A cross-sectional study of 200pre- and post menopausal women was carried out at SLIMS,Pondicherry. Bone formation markers (Total Calcium, Ionised calcium, Alkaline phosphatase), and bone resorption markers (Urinary Hydroxyproline) were analysed in pre and post menopausal women. Bone formation markers, Total and Ionised calcium were significantly decreased (p<0.001) and Alkaline phosphatase was significantly increased (p<0.001) in postmenopausal women compared to premenopausal women. Bone resorption markers, Urinary hydroxyproline excretion was significantly increased (p<0.001) in postmenopausal women. Measurement of bone turnover through urinary hydroxyproline,Alkaline phosphatase and Calcium could form a tool available to assist health care professionals to predict fracture risk. Early prediction of osteoporosis has important public health and clinical implications, as osteoporosis usually has no symptoms until the occurrence of fractures.