Clinical Profile Of Sero-positive Hepatitis A and Co-infection with Hepatitis E In Hospitalized Children

Dr. Anurag Gupta

Volume : VIII, Issue : II, February - 2019

Clinical Profile Of Sero-positive Hepatitis A and Co-infection with Hepatitis E In Hospitalized Children

Dr. Anurag Gupta

Abstract :

Introduction: Hepatitis A and hepatitis E both are enterically transmitted disease and a burden to developing countries like India. Both follow a similar course of disease and have a high chance of occurring together. Co-infection may lead to increased morbidity and mortality. Aims: To study the clinical profile of hospitalized Hepatitis A patients and to compare clinical profile of co-infection (Hepatitis A virus and Hepatitis E virus). Materials and methods: Cross sectional were observational study of 100 Hepatitis A patients admitted in pediatric ward of tertiary care hospital of age between 1 year and 12 years of age. Results: Out of 100 patients, 83 infected with HAV only while 17 had co-infection with HEV. HAV mostly affects preschool children while co-infection was reported in early adolescents. There was increased hospitalization of co-infected patients. On correlation of liver function tests, mean SGPT on admission and mean Bilirubin on admission both were higher in co-infected patients. Clinically, coinfection of HAV and HEV infection, though runs a more complicated and prolonged course does not affect the prognosis of patients. Conclusion: Even though hepatitis A and hepatitis s E infections are a self-limiting disease in pediatric age group and runs a relatively uncomplicated and benign course, it is the most common cause of fulminant hepatic failure in children. Thus, efforts have to be taken to curb the spread of disease in the community.