Clinical profile, Etiological profile, Severity and Outcome of Febrile thrombocytopenia patients: A Hospital-Based Cross-sectional study.

Shah Arth; Basu Abhijit; Dudhatra Ashutosh.

Volume : IX, Issue : II, February - 2020

Clinical profile, Etiological profile, Severity and Outcome of Febrile thrombocytopenia patients: A Hospital-Based Cross-sectional study.

Shah Arth, Basu Abhijit, Dudhatra Ashutosh.

Abstract :

Background: Fever with thrombocytopenia is commonly caused by infection like Malaria, Dengue fever, Enteric fever, leptospirosis and septicemia. The present study was intended to know the underlying etiology of feile thrombocytopenia in our community, various presentations and relationship between platelet count and severity of disease and outcome. Aims and objective: To study the clinical presentation, etiological profile and severity of thrombocytopenia and the disease outcome of patients with feile thrombocytopenia. Material and Method: This study was conducted in the department of general medicine of Geetanjali Medical College and Hospital, Udaipur from July 2018 to December 2018. 100 patients of >18 years of age admitted to the hospital with documented fever of >99.90 F and platelet count < 1,50,000 cells/cumm were included in study. Results: Among the total 100 patients admitted, 56 patients were male and 44 patients were female. Fever with chills and rigors (92%) and body pain (80%) were commonly observed symptoms. Hepatomegaly (33%) and splenomegaly (32%) were commonly observed signs. 47% cases presented with moderate thrombocytopenia in which maximum cases were due to malaria (36%) and 43% cases presented with severe thrombocytopenia in which maximum cases were from dengue fever. Most common etiology of feile thrombocytopenia was found to be dengue fever (36%) followed by malaria (29%). It was found that 8 patients expired out of which 2 had scrub typhus, 3 had malaria, 3 had dengue fever respectively. Most likely cause was multiorgan dysfunction (MODS). Conclusion: fever with thrombocytopenia is an important clinical condition commonly caused by infections, particularly Dengue, malaria and septicaemia. Mortality in feile thrombocytopenia is not directly associated with degree of thrombocytopenia but with concomitant involvement of other organs leading to multiorgan dysfunction.