Clinical Outcome Of Neoadjuvant Chemotherapy Followed by Chemoradiation in Locally Advanced Carcinoma Of Rectum

Dr. Swapan Kumar Mallick

Volume : IX, Issue : VI, June - 2020

Clinical Outcome Of Neoadjuvant Chemotherapy Followed by Chemoradiation in Locally Advanced Carcinoma Of Rectum

Dr. Swapan Kumar Mallick

Abstract :

Introduction: Rectal cancer is the growth of abnormal cancerous cells in the lower part of the colon that connects the anus to the large bowel. Colorectal cancer is the third most common cancer in men and the second in women worldwide. Materials & Methods: Locally advanced rectum cancer attending the Out Patient Department of Radiotherapy from August 2018 to January 2020, meeting specified Inclusion and Exclusion Criteria, willing to participate in the study were included. The clinical outcome, acute and late side effects, loco-regional control and recurrence of each patient were assessed. Results: The characteristic toxicities, and response were assessed using the common terminology criteria for adverse events (CTCAE) version 4.0. After 3 cycles of NACT radiological response was 3.58%, Partial response 78.58%, Stable disease 7.14% and Progressive disease 10.70% and feasibility of surgical resection were 92.90%. Conclusions: NACT followed by chemoradiation, represent the standard of care. Pre-operative CTRT have greatly lowered the rates of local recurrence.