Volume : VI, Issue : IV, April - 2017

Clinical outcome of dexamethasone and methotrexate drugs on rheumatoid arthritis

Dr. Dharmendra Garg

Abstract :

 Serum IL6 levels of patients with RA have been associated with disease outcome, The T cell derived cytokine IFN-alpha is also produced by natural killer cells (NK cells) and is involved in nearly all phases of inflammation and in the regulation of inflammatory responses. It has effects on macrophage, B cell, and neutrophil function. The inhibition of IFN-alpha, as seen in this study, might be the result of inhibition of DHODH, which impairs T cell function with, as secondary effect, inhibition of monocyte/macrophage function. This is supported by the inhibition which occurs at concentrations of active metabolite present in patients with RA .

 

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

DR.DHARMENDRA GARG, Clinical outcome of dexamethasone and methotrexate drugs on rheumatoid arthritis, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-6, Issue-4, April‾2017

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