Clinical evaluation of the breath test with mixed triglycerides in chronic pancreatitis

S. Siminkovitch; B. Vladimirov; M. Kovacheva-Slavova

Volume : V, Issue : VI, June - 2016

Clinical evaluation of the breath test with mixed triglycerides in chronic pancreatitis

S. Siminkovitch, B. Vladimirov, M. Kovacheva Slavova

Abstract :

 The main objective of this study was to determine sensitivity and specificity of C13 labeled eath test with mixed triglycerides (¹³C-MTG BT) in patients with chronic pancreatitis (CP), and to compare results to imaging CT/MRCP data and Fecal-elastase-1. Study encompassed 40CP patients (26 males); mean aged 53.29 ± 14.09. Patients were divided according to CT/MRCP Camidge classification. ¹³C-MTG BT3 was analyzed by a mass-spectrometry and FE-1 by ELISA (ScheBo® Biotech). Results: 30% of the patients were positive for ¹³C-MTG BT. We found a difference between ¹³C-MTG BT mean values for CT/MRCP subgroups 1-4, p<0.001. ¹³C-MTG BT sensitivity and specificity for severe diseasewere80% and 85%. Agreement between ¹³C-MTG BT and FE-1 was 78%. Conclusion: there was a relationship between ¹³C-MTG BT levels and severity of morphological imaging data and FE-1 results. The combination of both tests, FE-1 and ¹³C-MTG BT may contribute to better PEI detection.