Clinical efficacy of Nalbuphine versus Butorphanol as analgesic adjuvant to fentanyl during surgical procedures under general anesthesia- A double blind comparative study

Salony Agarwal; Kumkum Gupta; Abhishake Kumar; Kopal Gupta; Pavitra Kalra; Sukhreet Kaur

Volume : VIII, Issue : II, February - 2019

Clinical efficacy of Nalbuphine versus Butorphanol as analgesic adjuvant to fentanyl during surgical procedures under general anesthesia- A double blind comparative study

Salony Agarwal, Kumkum Gupta, Abhishake Kumar, Kopal Gupta, Pavitra Kalra, Sukhreet Kaur

Abstract :

Background- Noxious stimulation of surgery predictably leads to variable hemodynamic changes which can be modified by intraoperative opioid analgesia. The present study was aimed to comparatively evaluate the clinical efficacy of Nalbuphine with Butorphanol as analgesic adjuvant to fentanyl during surgical procedures under general anesthesia. Method and Material- Sixty adult patients of ASA grade I and II of either sex, were randomized into two equal groups of 30 patients each. Patients of Group I N received Nalbuphine 10 mg and patients of Group II B received Butorphanol 2 mg intravenously, 15 min before induction of general anesthesia with propofol. The endotracheal intubation was facilitated by vecuronium omide (0.1mg/kg) and anesthesia was maintained with isoflurane, nitrous oxide and oxygen. Changes in heart rate and systemic blood pressure were noted as primary variables and postoperative nausea, vomiting, respiratory depression, shivering or pruritus were noted as secondary outcomes. Results- Patients of comparable demographic profile showed fall in heart rate and blood pressure after nalbuphine, but intraoperative hemodynamic changes were comparable between the groups. After extubation, patients of nalbuphine group were sedated but arousable while patients of butorphanol group were awake. No episode of nausea, vomiting, respiratory depression, shivering, pruritus or any other side effects occurred in any patient. Conclusion- Nalbuphine and butorphanol, both could provide effective intraoperative analgesia as well as attenuated the hemodynamic response to surgical stress of surgical procedures.