CHRONIC MYELOID LEUKEMIA: REVIEW OF PATHOGENESIS AND DIAGNOSIS.

Tanya Tripathi; Noorin Zaidi; S. Riaz Mehdi

Volume : VIII, Issue : IV, April - 2019

CHRONIC MYELOID LEUKEMIA: REVIEW OF PATHOGENESIS AND DIAGNOSIS.

Tanya Tripathi, Noorin Zaidi, S. Riaz Mehdi

Abstract :

Chronic Myeloid Leukemia (CML) is one of the commonest leukemias in adults. Its pathogenesis involves translocation between chromosome 9 and 22 which results in abnormal tyrosine kinase activity. The disease has three phases with different criteria for diagnosis. Various modalities are used for making a diagnosis of CML as well as for predicting prognosis and for therapeutic planning. The following article, therefore, is written to review the current concept of pathogenesis and the different diagnostic modalities.