CASE SERIES OF PROTEIN C AND PROTEIN S DEFICIENCY IN THROMBOGENIC EVENTS

Dr. Diguvinti Sreeramulu; Dr. P C Vasanth Rao; Dr. P Rama Rao; Dr Sunitha; Dr M Sohail Malik

Volume : V, Issue : V, May - 2016

CASE SERIES OF PROTEIN C AND PROTEIN S DEFICIENCY IN THROMBOGENIC EVENTS

Dr. Diguvinti Sreeramulu, Dr. P C Vasanth Rao, Dr. P Rama Rao, Dr Sunitha, Dr M Sohail Malik

Abstract :

Thrombophilia is a disorder characterized by an increased incidence of arterial and venous thrombosis. It may be acquired or hereditary. Protein C and Protein S deficiency with or without high Homocysteine levels have been reported to be associated with thrombogenic events. AIM: To find protein C, protein S deficiency and hyperhomocysteinemia as the risk factors for thrombogenic events through a retrospective analysis of patients admitted in the medicine department with thrombogenic events over a period of 1 year were evaluated. MATERIALS AND METHODS: Total 10 patients with thrombogenic events were reviewed with history, clinical findings and investigation reports. The data analyzed to find the risk factors associated. Protein C, Protein S and Homocysteine levels were evaluated on a fully automated coagulometer. Acquired causes of were excluded. RESULTS: Average age of the patient was 30 years with male predominance in 60%. Thrombogenic events was mainly in the form of cereovascular accidents in 40% (4 of 10) patients . Protein C deficiency occurred in 50% (5 of 10) patients, while Protein S deficiency in 80%( 8 of 10) patients. Combined Protein C and S deficiency occurred in 40%(4 of 10) patients. Hyperhomocysteinaemia was documented as a predisposing factor in 20( 2 of 10) patients. CONCLUSION: We conclude that, the frequency of protein C deficiency, protein S deficiency and hyperhomocysteinemia are significantly higher among those with thrombogenic events than general population and hence need to be screened for in all thrombogenic events.