C - reactive protein: An inflammatory biomarker present in multiple disease pathogenesis

Parvinder Kaur; Ikram Qureshi; Prashant Khadke

Volume : VIII, Issue : X, October - 2019

C - reactive protein: An inflammatory biomarker present in multiple disease pathogenesis

Parvinder Kaur, Ikram Qureshi, Prashant Khadke

Abstract :

C-reactive protein (CRP) is an acute-phase protein belongs to pentraxins family with a feature of five identical globular subunits. Two different isoforms i.e. pentameric CRP (pCRP) and monomeric CRP (mCRP) have different key role in regulation. The key biological function of CRP is host defense using classical complement pathway against bacterial infection and involved in removal of apoptotic and necrotic cells. Although CRP is mainly associated with inflammation in bacterial infection such as tuberculosis or Pneumococcus infection, however it is also presence in atherosclerosis, cardiovascular disease (CVD) and in various cancers which make it good candidate for prognostic study in different clinical conditions.