Volume : V, Issue : V, May - 2016

Biological analyses for understanding of the uterine sarcomagenesis

Miki Kawano, Takuma Hayashi

Abstract :

 Soft tissue sarcomas are neoplastic malignancies that typically arise in tissues of a mesenchymal origin. The identification of novel molecular mechanisms leading to sarcoma formation and the establishment of new therapies and biomarkers have been hampered by several critical factors. This type of cancer is rarely observed in clinical settings, with fewer than 15,000 new cases being diagnosed each year in the United States. Another complicating factor is that soft tissue sarcomas are extremely heterogeneous as they arise in a multitude of tissues from many different cell lineages. The scarcity of clinical samples coupled with its inherent heterogeneity creates a challenging experimental environment for clinicians and scientists. Faced with these challenges, there have been extremely limited advances in treatment options available to patients with soft tissue soft tissue sarcomas compared with those for patients with other cancers. In order to glean insight into the pathobiology of soft tissue sarcomas, scientists are now using mouse models whose genomes have been specifically tailored to carry gene deletions, gene amplifications, and point mutations commonly observed in human soft tissue sarcomas. The use of these model organisms has been successful in increasing our knowledge and understanding of how alterations in relevant oncogenic, tumour suppressive, and signaling pathways directly impact sarcomagenesis. It is the goal of many in the biological community that the use of these mouse models will serve as powerful in vivo tools to further our understanding of sarcomagenesis and potentially identify new biomarkers and develop therapeutic strategies.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Miki Kawano, Takuma Hayashi Biological analyses for understanding of the uterine sarcomagenesis Global Journal For Research Analysis, Vol: 5, Issue : 5 MAY 2016

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