BIOCHEMICAL PROFILE IN PATIENTS WITH MALARIA : AN OBSERVATIONAL STUDY

Kadappa Jaligidad; Sneha Patil; Sunil Baragi

Volume : VIII, Issue : I, January - 2019

BIOCHEMICAL PROFILE IN PATIENTS WITH MALARIA : AN OBSERVATIONAL STUDY

Kadappa Jaligidad, Sneha Patil, Sunil Baragi

Abstract :

Background- Malaria is a acute feile illness being endemic in 104 countries and India contributing to 5% total cases and 4% of mortalities worldwide. Severe malaria is known to affect all the vital organs in the body. This study was conducted to assess the liver and renal impairment in malaria cases. Methods- This is a retrospective observational study conducted among 104 patients with malaria coming to HSK Hospital and SNMC , Bagalkot during January 2017 to June 2018. Study group included all the patients diagnosed either by smear showing malarial parasite or by rapid diagnostic test for malarial antigen. Patients with chronic liver disease and chronic kidney disease were excluded from the study. Laboratory values like LFT, RFT, RBS and serum electrolytes were collected and analysed. Results were expressed in terms of percentage. Results- Among the 104 malaria patients, 61 (59%) were males and 43(41%) were females. Age group from 15 to 30 years had highest incidence(47%). 57 patients (55%) had total bilirubin > 1mg/dl, 62 patients (59%) had serum albumin of <3.5mg/dl , 53 patients ( 51%) had SGOT >40IU/L , 38patients (36%) had SGPT >40 IU/L. 22patients (21%) had blood urea > 40mg/dl, 16 patients (15%) had serum creatinine > 1.2mg/dl. Among 104, 31 patients (29%) had hyponatremia with serum Na <135meq/L, 4 patients ( 3%) had serum Na >155meq/L. 20 patients (19%) had serum potassium <3.5mEq/L. 9 patients (8%) had random blood glucose of < 70mg/dl. Conclusion- P.vivax is more common than P.falciparum infection. Liver and renal function derrangement , hypokalemia, hyponatremia are commonly seen in malarial infection.