BACTERIOLOGICAL PROFILE AND ANTIMICROBIAL SENSITIVITY PATTERNS IN NEONATAL SEPSIS: A STUDY FROM EASTERN INDIA

Debasree Guha; Angshumitra Bandyopadhyay

Volume : VIII, Issue : VI, June - 2019

BACTERIOLOGICAL PROFILE AND ANTIMICROBIAL SENSITIVITY PATTERNS IN NEONATAL SEPSIS: A STUDY FROM EASTERN INDIA

Debasree Guha, Angshumitra Bandyopadhyay

Abstract :

Background: Neonatal sepsis is a leading cause of neonatal mortality and continues to be a formidable problem for neonatologists and pediatricians worldwide. Objective: The study was carried out to determine the bacteriological flora prevalent in the neonatal care unit of a tertiary care hospital from Eastern India and their antimicrobial sensitivity pattern. Materials and Methods: The blood culture reports of all neonates with culture positive sepsis during the period from January 2016 to December 2018 were reviewed retrospectively. The data was entered in excel sheets and necessary calculations were done accordingly. Results and Analysis: Of the 21,113 neonates admitted during this period, 163 had culture positive sepsis, accounting for 7.7 cases of neonatal sepsis per 1000 live births. Gram negative isolates were obtained in 72.39% cases, gram positive in 19.02% cases and 8.6% were mixed isolates. Majority of the cases were late onset sepsis category (68.1%). Acinetobacter baumanii complex was the most frequently isolated organism in both early and late onset sepsis cases. Gram negative isolates were mostly sensitive to Carbapenems and Polymyxin B, whereas gram positive cases had good sensitivity to Vancomycin and Linezolid. Conclusion: Knowledge of the microbial flora and their susceptibility patterns will help us to decide judicious empirical treatment for neonatal sepsis.