B-cell Non-Hodgkin's lymphoma of the sinonasal tract: A Review of A Single Institution Experience In North India

Dr. Mukesh Sonkaria; Dr. R. K. Tanwar; Dr. Laxmi Agarwal; Dr. Bharti Saxena

Volume : IX, Issue : IV, April - 2020

B-cell Non-Hodgkin's lymphoma of the sinonasal tract: A Review of A Single Institution Experience In North India

Dr. Mukesh Sonkaria, Dr. R. K. Tanwar, Dr. Laxmi Agarwal, Dr. Bharti Saxena

Abstract :

Objectives: This study aims to review the current literature and to study the etiopathogenesis, clinical profile, diagnosis, treatmentprotocols & outcome of sinonasalB-cell lymphoma. Materials and Methods: A retrospective study of sinonasal lymphoma from January 1997 to Dec 2019. We hereby share our experience of 7 cases of sinonasalB-cell lymphoma. Results: A total of 7 cases of thesinonasal B-cell lymphoma (six diffuse large B-cell lymphoma(DLBCL)& one follicular) were identified. The average age of presentation was 45 years (range 2 to 89 years), with a male predominance. All patients had an ECOG score of 1. Paranasal sinus (PNS) and nasal cavity together were most common sites involved in 5 patients. PNS only were involved in 2 patients. Maxillary sinus was the most frequently involved site (100%) with or without PNS followed by nasal cavity (71%). Out of 7 patients, 3 (43%) received chemo-radiotherapy, three patients received chemotherapy alone and one received radiotherapy alone..The mean progression-free survival (PFS) rate was 53 months and mean overall survival (OS) was 57 months. Chemotherapy and radiation therapy resulted in improved survival. In majority of cases recurrence developed locally. Conclusion: primary sinonasal lymphomas exhibit different clinical profiles, different patterns of failure, and different treatment outcomes due to which they carry poor prognosis, usually worse than lymphomas in other sites in the body. Multidrug chemotherapy (R-CHOP regimen) followed by radiotherapy appears to be the most effective treatment approach.