ATTENUATION OF PRESSURE RESPONSE DURING LARYNGOSCOPY AFTER USING NITROGLYCERINE AND ESMOLOL -A COMPARATIVE STUDY.

DR.SOMA CHAKRABORTY; DR. SAIKAT MAJUMDAR; DR. NEETA BASAK; PROF. G. VIJAYALAXMI; DR.HARIPADA DAS; PROF. DILIP KUMAR ADHIKARI; DR.TAPABROTA MITRA

Volume : VII, Issue : VII, July - 2018

ATTENUATION OF PRESSURE RESPONSE DURING LARYNGOSCOPY AFTER USING NITROGLYCERINE AND ESMOLOL -A COMPARATIVE STUDY.

Dr. Soma Chakraborty, Dr. Saikat Majumdar, Dr. Neeta Basak, Prof. G. Vijayalaxmi, Dr. Haripada Das, Prof. Dilip Kumar Adhikari, Dr. Tapabrota Mitra

Abstract :

BACKGROUND- Pressure response after direct laryngospy produces deleterious effects on patients. Different drugs and methods are tried to abolish this responces. Efficacy of a continuous infusion of esmolol and nitroglycerine in attenuating the haemodynamic response to direct LI in elective surgery under general anaesthesia evaluated in this study.

Materials and Methods- 150 patients randomly allocated in three equal groups. Group E received esmolol 100 �g/kg/minute intravenous, Group N received nitroglycerine 0.5 �g/kg/minute i.v. and Group C (control) received 50 cc normal saline infusions. Pulse rate (PR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) compared in three groups.

Results- Esmolol showed lowest pulse rate 1, 3, 5 post intubation minutes (4.94�9.91, 1.56�7.96,-1.96�7.222) respectively. At 3 and 5 minutes esmolol has reduced mean SBP below the pre-intubation level (-4.4 and –10.34 respectively). Whereas in nitroglycerine group reduction of mean SBP below pre-intubation level found at 5 minutes after intubation (-6.98). Esmolol effectively ing down the DBP at normal level at 3 minutes (0.78�7.49). At 5 minutes after intubation both nitroglycerine (-4.14�5.96) and esmolol (-3.48�7.34) has ought down the DBP below pre-intubation level. At 3 minutes mean MBP in esmolol group reduced to below pre-intubation level (-0.96) and the same changes occurred in both esmolol and nitroglycerine group at 5 minutes after intubation (-5.71 and -5.08 respectively) .

Conclusion- We conclude that Esmolol was more effective than Nitroglycerine in controlling the hemodynamic responses to direct laryngoscopy and endotracheal intubation