ATTENUATION OF HEMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATION USING ORAL IVABRADINE - A PROSPECTIVE RANDOMISED CONTROLLED DOUBLE BLIND STUDY

Dr. Syed Rubiya Sultana; Dr. Renu Devaprasath; Dr. S.Nishal Perumal; Dr Renjith I

Volume : IX, Issue : III, March - 2020

ATTENUATION OF HEMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATION USING ORAL IVABRADINE - A PROSPECTIVE RANDOMISED CONTROLLED DOUBLE BLIND STUDY

Dr. Syed Rubiya Sultana, Dr. Renu Devaprasath, Dr. S. Nishal Perumal, Dr Renjith I

Abstract :

BACKGROUND:Rapid and dramatic hemodynamic changes which adversely affect the patient may occur during laryngoscopy and intubation. The present study evaluates the effect of oral ivaadine on the hemodynamics during laryngoscopy and endotracheal intubation in patients undergoing surgical procedures under general anesthesia with ETT. STUDY DESIGN: A prospective, randomized, controlled, double-blind study. MATERIAL AND METHODS : 90 ASA I and II patients who underwent elective surgeries under general anaesthesia at Dr Jeyasekharan Hospital and Nursing Home, were randomly divided into two groups of 45 each. Group A received Tab Ivaadine 5 mg and group B received Tab B complex.The hemodynamic parameters namely HR,SBP,DBP and MAP were monitored prior to the study drug as baseline and at the following time intervals ;after induction, after intubation, ,after 1,3,5,8 and 10 minutes after intubation. RESULTS: HR was significantly lower in the ivaadine group compared to control group at all time interval after study drug. SBP,DBP&MAP were significantly lower in the Ivaadine group compared to control group after induction, after intubation, and 1,3,5,8 and 10 minutes after intubation. CONCLUSIONS: Ivaadine given before intubation prevents significant rise in HR and SBP, DBP, MAP compared to placebo in patients during laryngoscopy and endotracheal intubation.