Association of 25 (OH) Vitamin D Levels with Increased Procalcitonin Levels in Septic Patients at H. Adam Malik General Hospital Medan

Maruhum Nur; Adi K. Aman; Achsanuddin Hanafie

Volume : VIII, Issue : X, October - 2019

Association of 25 (OH) Vitamin D Levels with Increased Procalcitonin Levels in Septic Patients at H. Adam Malik General Hospital Medan

Maruhum Nur, Adi K. Aman, Achsanuddin Hanafie

Abstract :

Introduction: Sepsis is a complex syndrome caused by an uncontrolled systemic inflammatory response, caused infection. One factor that plays a role in the prognosis of sepsis is vitamin D. While Procalcitonin (PCT), a biomarker response to infection, and PCT levels can be increased in septic patients. The purpose of this study was to determine the association of 25 (OH) Vitamin D levels with increased PCT levels in septic patients. Methods: This study was conducted with cross sectional design, from August to December 2016. The subjects of this study were septic patients who admitted to the intensive care unit at H. Adam Malik General Hospital Medan, aged >18 years. 25 (OH) vitamin D total and Procalcitonin (PCT) were measured by means of MINI VIDAS BRAHMS, correlation of 25 (OH) Vitamin D and PCT levels was tested using Spearman correlation test, statistical tests with p values <0.05 were considered significant. Results and Discussions: A sample of 33 people consisted of 20 (60.6%) men and 13 (39.4%) women, with an average (SD) age of 53.6 (11.7) years. There were 27 (81.8%) patients reporting hypovitaminosis Vitamin D. That was found a significant negative correlation of total 25 (OH) vitamin D levels with procalcitonin levels (r = - 0.434, p = 0.012). Conclusions: In this study concluded that 81.8% of patients who treated in the ICU had hypovitaminosis Vitamin D. There was a negative correlation between 25 (OH) vitamin D levels and increased procalcitonin levels of septic patients who admitted to the ICU.