Assessment of pituitary and thyroid function in neonates with perinatal asphyxia

Reetika Saini; Siddarth Ramji; Vedika Bhat; Bidhan Chandra Koner; Sarika Arora

Volume : VIII, Issue : II, February - 2019

Assessment of pituitary and thyroid function in neonates with perinatal asphyxia

Reetika Saini, Siddarth Ramji, Vedika Bhat, Bidhan Chandra Koner, Sarika Arora

Abstract :

Aim : The present study was designed to evaluate pituitary and thyroid functions in perinatal asphyxia and their prognostic significance. Method: Cord blood samples from 38 cases of perinatal asphyxia (those with APGAR score <6 at 5 minutes ) and 38 healthy controls were assessed for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), prolactin and growth hormone (GH). Venous blood samples of perinatal asphyxia cases were reassessed for these parameters after 48-72 hrs . Results: Mean cord blood GH, prolactin , TSH and Free T3 levels were significantly higher in cases and no significant difference was observed in Free T4 levels. Serum Prolactin levels showed significant negative correlation with duration of assisted ventilation. Receiver operating characteristics curve showed that cord blood FT3 level can predict short-term prognosis in perinatal asphyxia at optimum cut off of 2.62pmol/L. Conclusions: Perinatal asphyxia has significant impact on pituitary and thyroid function