Assessment of endocrine dysfunction and iron overload in multi-transfused Bangladeshi Thalassemia patients.

DR. MD. BELAYET HOSSAIN

Volume : VII, Issue : IV, April - 2018

Assessment of endocrine dysfunction and iron overload in multi-transfused Bangladeshi Thalassemia patients.

Dr. Md. Belayet Hossain

Abstract :

In transfusion dependant Thalassemia patients under transfusion, and multiple transfusion along with inadequate chelation therapy leading to iron overload may cause endocrine complications. The aims of this study are to assays the endocrine dysfunctions and their correlation with iron overload. This retrospective study assays multi-transfused thalassemic children in Dhaka Shishu(Children) Hospital Thalassemia Centre of Dhaka Shishu(Children) Hospital. Among 135 patients, age range was 12-18 years and mean was 14.6 � 2.50 years, 72(53%) were boys and 63(47%) were girls. Mean serum FSH was 1.37 � 1.05 mIU/ml,normal in 21(33 %) and low in 43(67%) girls. Mean level of LH was 1.67 � 2.05 mIU/ml, normal in 28(44%) and low in 36(56%) girls.Mean testosterone level was 16.30 � 1.35 ng/dl, normal in 10(14%) and low in 61(86%) boys. Mean serum TSH was 3.37 � 1.05 mIU/ml,normal in 103(7 6%) and high in 32(24 %) study population. Mean serum PTH was 58.63 �7.47 pg/ml, normal in 105(77.2%), low in 13(9.7%) and high in 17(12.5 %) study population. Correlation between different hormonal imbalances with serum ferritin level was not found. The high prevalence of endocrine dysfunctions in this study justifies the need for regular follow-up of multi-transfused thalassemic children for early detection and appropriate treatment of endocrine dysfunctions.