APOPTOTIC INDEX- A PROGNOSTIC PARAMETER IN ENDOMETRIAL LESIONS - HYPERPLASIA AND CARCINOMAS

DR NATASHA MAKKAR

Volume : VII, Issue : IX, September - 2018

APOPTOTIC INDEX- A PROGNOSTIC PARAMETER IN ENDOMETRIAL LESIONS - HYPERPLASIA AND CARCINOMAS

Dr Natasha Makkar

Abstract :

Background:Endometrial cancer is the most common gynaecological malignancy affecting women in developed countries and the second most common gynaecological malignancy world-wide.The apoptotic index, defined as the percentage of morphologically identified apoptotic cells per 100 non apoptotic cells.Apoptosis is observed at increasing levels in the hyperplasia, atypia, adenocarcinoma sequence. Methods: In all hysterectomy cases, histological findings and apoptotic index was noted. The cases were divided into five categories. Mean apoptotic index was calculated in each category and comparison was done.Results:Edometrialcarcinoma had significantly higher apoptotic index than other categories (p-value =0.000). An increasing mean apoptotic index was noted in complex hyperplasia categories than in simple hyperplasia ones. Conclusion: Apoptotic index gradually increases with increasing complexicity in endometrium.