Antioxidant Effect of vitamin A & E on Heavy metal (Cd) Induced Renal, Testicular as well as Hepatic injury in Male Albino mice

Volume : IV, Issue : IV, April - 2015

Rajesh Ku. Meher, Namita Nayak, Bhaskar Behera

Heavy metal toxicity is world threatening problem for human as well as other organism. Heavy metal is widely

distributed in environment and some of them occur in food, water, air. Exposure of heavy metal induced oxidative

stress and renal and testicular as well as hepatic injury were evaluated in male mice. Present study is desired to find out

whether vitamin A & E is able to protect the heavy metal (Cd) stress injury to kidney, liver, testicular abnormality. For these purpose 15 numbers of

male albino mice were taken and acclimatization on laboratory condition for about 15 days. 15 mice were divided in to 3 different group each

group contain 5 mice first group served as control and was given only distilled water, the second group received distilled water supplemented

with Cd 10mg per Kg body weight, third group received distilled water supplemented with 10 mg Cd/kg body weight with Vitamin Cd/kg per day

for 90 days. Tissue were collected from both control and treated animals and studied. Mice exposure to Cd show histopathological changes in the

liver, kidney, testis but not in Cd supplemented with vitamin A & E