Antibiotic Resistance Pattern Among Gram-negative Bacilli involved in Lower Respiratory Tract Infections

Akansha Rana; Ajitesh kumar Mishra; Monika Rathee

Volume : IV, Issue : XII, December - 2015

Antibiotic Resistance Pattern Among Gram-negative Bacilli involved in Lower Respiratory Tract Infections

Akansha Rana, Ajitesh Kumar Mishra, Monika Rathee

Abstract :

The study was aimed at determining the prevalence and antibiotic resistance among Gram-negative Bacilli isolated from the lower respiratory tract of patients attending our tertiary care centre. Lower respiratory tract secretions (tracheal aspirate and sputum) of 500 patients were cultured, identified and antimicrobial susceptibility was performed by standard methods. Out of 500 patients, 216 were culture positive. Out of which 152 were GNB, 45 were Staphylococcus aureus and 19 were Candida spp. The common GNB isolates were non-fermentative gram-negative bacilli (NFGNB, 34.2%), followed by Klebsiella spp(21.7%) and Pseudomonas aeruginosa (21%). In both tracheal and sputum GNB isolates, the highest mean resistance was to ampicillin(87.4%) and cefazolin(75.2%) while lowest to imipenem(12.8%) and amikacin(30.5%). A large majority of the isolated multidrug resistant Gram-negative bacilli were found to be pathogenic. Regular surveillance and good clinic-microbiological workup can reduce morbidity and mortality associated with multidrug resistant organisms.