Analgesic efficacy with intravenous dexmedetomidine with intraperitoneal instillation of levobupivacaine in elective laparoscopic cholecystectomies under general anaesthesia

Dr. Arjun Singh

Volume : IX, Issue : IV, April - 2020

Analgesic efficacy with intravenous dexmedetomidine with intraperitoneal instillation of levobupivacaine in elective laparoscopic cholecystectomies under general anaesthesia

Dr. Arjun Singh

Abstract :

Background: Post-operative pain is of major concern following laparoscopic cholecystectomy which results in reduced patients� comfort and longer hospital stay. Aim: Analgesic efficacy with intravenous dexmedetomidine with intraperitoneal instillation of levobupivacaine in elective laparoscopic cholecystectomies under general anaesthesia Patients and Methods: This prospective, randomized, double-blind controlled study was conducted on 70 adults of ASA physical status I and II, scheduled for laparoscopic cholecystectomy under general anaesthesia. Patients were randomized to one of the two groups (n= 35 each). Group A received intravenous 10 ml normal saline (NS) over 10 minutes before extubation along with intraperitoneal instillation of 28 mL Levobupivacaine 0.25% with 2ml of normal saline, while groups B dexmedetomidine 0.5 �g/kg intravenous (IV) in 10 ml normal saline (NS) over 10 minutes before extubation along with intraperitoneal instillation of levobupivacaine to total volume of 30 ml. Visual analogue scale (VAS), sedation score, time to require first dose of rescue analgesia, and side effect profile noted. Results: Intravenous dexmedetomidine provided significantly higher degree of sedation, and reduced post-operative pain, and increased time to require first dose of rescue analgesia. Side effect profile was comparable. Conclusion: Intravenous dexmedetomidine may be an alternate choice to manage post-operative pain during laparoscopic cholecystectomy.