AMELIORATIVE EFFECT OF CINNAMALDEHYDE AGAINST LEAD ACETATE INDUCED SPLENIC TOXICITY OF SWISS ALBINO MICE (Mus musculus)

Papiya Datta; Dr. Soumosish Paul; Prof. (Dr.) Gobinda Chandra Sadhukhan; Prof. (Dr.) Nimai Chandra Saha; Dr. Soumendranath Chatterjee

Volume : IX, Issue : VIII, August - 2020

AMELIORATIVE EFFECT OF CINNAMALDEHYDE AGAINST LEAD ACETATE INDUCED SPLENIC TOXICITY OF SWISS ALBINO MICE (Mus musculus)

Papiya Datta, Dr. Soumosish Paul, Prof. Dr. Gobinda Chandra Sadhukhan, Prof. Dr. Nimai Chandra Saha, Dr. Soumendranath Chatterjee

Abstract :

Our mother India is full of various herbal plants with great medicinal importance. Cinnamaldehyde, an active component of Cinnamon, one of the widely used spice has antifungal, anti-microbial, anti-oxidative and many other properties. Our present study is aimed to investigate the ameliorative effect of Cinnamaldehyde upon the splenic toxicity induced by chronic lead exposure. For this lead acetate was applied on female Swiss albino mice (Mus musculus) continuously for 120 days. After treatment with lead, only selective dose of Cinnamaldehyde was applied on the mice for last 30 days. For observing the hazardous effects of this heavy metal and curative effect of Cinnamaldehyde, we explored various biological parameters like TBARS, GSH along with morphometric and histo-pathological analysis. Our observations clearly depicted the dose-dependent ill effects of this toxic heavy metal. Post –treatment of Cinnamaldehyde at a selective dose helped the tissue to get rid of this toxicity at certain level. All these findings disclosed the ameliorative effects of Cinnamaldehyde upon lead toxicity on spleen.