Volume : VII, Issue : X, October - 2018

AgNORs IN BENIGN AND MALIGNANT BREAST LESIONS

Dr. Vijay Tote, Dr. Dhananjay Prasad, Dr Brajendra Kumar

Abstract :

Objective of our study was to  assess usefulness of argyrophilicnucleolar organizer regions (AgNORs) in

distinguishing between the benign and the malignant east lesions.The studied samples included 48 formalin-fixed, paraffin-embedded east tissueswhich consist of following diagnostic categories: Adenosis (n=8), ductal hyperplasia (n=6), infiltrativeductal carcinomas (n=14), infiltrative lobular carcinomas (n=5), and ductal carcinomas in situ (n=5).

Standardized AgNORs analysis was performed on the above mentioned samples according to the guidelines of the committee on AgNORs. Quantification of AgNOR content was done by the usualcounting method.The mean AgNORs counts of these studied cases were as follow : Adenosis 2.59+/-0.54,ductal hyperplasia 3.15+/-0.54, benign cysts 1.7+/-0.42, phylloides tumor 4.2+/-1.18, infiltrative ductalcarcinomas 8.92+/-1.68, infiltrative lobular carcinomas 8.79+/-1.11and ductal carcinomas in situ8.84+/-2.54. The differences in mean AgNORs counts between benign (2.58) and that of malignantlesions (8.84) were statistically significant (p-value 0.001).The use of AgNORs analysis is found to be a helpful tool in addition to theconventional hematoxylin and eosin staining technique for the distinction between benign andmalignant east lesions.

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Dr.Vijay Tote, Dr.Dhananjay Prasad, Dr Brajendra Kumar, AgNORs IN BENIGN AND MALIGNANT BREAST LESIONS, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7 | Issue-10 | October-2018

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