Aerobic Bacteriological Study of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in a tertiary care hospital in Hadoti region

Dr.Ghanshyam Soni; Dr.Gyan Prakash Tripathi; Dr.Anita Sharma; Dr.Khushboo Sharma

Volume : VII, Issue : I, January - 2018

Aerobic Bacteriological Study of Acute Exacerbations of Chronic Obstructive Pulmonary Disease in a tertiary care hospital in Hadoti region

Dr. Ghanshyam Soni, Dr. Gyan Prakash Tripathi, Dr. Anita Sharma, Dr. Khushboo Sharma

Abstract :

Background: The natural history of chronic obstructive pulmonary disease is characterized by frequent exacerbations. The purpose of this study was to determine the bacteriology of acute exacerbations of chronic obstructive pulmonary disease in hospitalized patients in our institution and their antibiotic susceptibility pattern to formulate cost effective antibiotic strategy and reducing the emergence of drug resistance. Materials and Methods: 50 clinically diagnosed cases of AECOPD admitted in medicine and chest wards were selected for the study. Direct gram stain was done for all sputum samples. The suitable sputum samples were cultured. Identification of organism and antimicrobial susceptibility testing was done by standard microbiological technique Results: Our study showed growth of pathogenic organisms in 41.12% cases. Males (61.90%) are more affected than females (23.71%). Gram negative bacilli were more isolated than gram positive cocci. Our study showed 21 positive sputum cultures and 76.20% were males and 23.80% were females. The prevalence of Gram negative bacteria was 71.42% and Gram positive bacteria were 28.58%. Klebsiells pneumoniae was the commonest bacteria isolated 6 (28.57%), followed by E.coli 4 (19.0%), Staphylococcus aureus, Streptococcus species & Pseudomonas aeruginosa ,each 3 (14.28%) & Acinetobacter species 2 (9.53%).The antibiotic susceptibility reveals that vancomycin, linezolid, azithromycin were most effective drugs for gram positive cocci, meropenem ,ceftriaxone,imipinem for gram negative bacilli and amikacin & piperacillin -tazobactam for both gram positive cocci & gram negative bacilli.Conclusion: In developing country like India AECOPD is common in adults more than 50 years of age due to smoking habits and high indoor pollution. This leads to a major impact on the quality of life of patients with the condition. They are a major cause of hospital admission and health care utilization