A STUDY ON THE EFFECT OF LISINOPRIL & OLMESARTAN IN DIABETIC NEPHROPATHY

Krishna Kant Nirala; Ritesh Kumar Sinha; Jaleshwar Prasad

Volume : IX, Issue : IV, April - 2020

A STUDY ON THE EFFECT OF LISINOPRIL & OLMESARTAN IN DIABETIC NEPHROPATHY

Krishna Kant Nirala, Ritesh Kumar Sinha, Jaleshwar Prasad

Abstract :

Introduction:Nephropathy is a major cause of illness and death in diabetes. Excess mortality in diabetes occurs mainly in proteinuric type 1 and type 2 diabetic patients and most of the patient die due to cardiovascular complication than End Stage Renal Disease (ESRD) as such particularly in type 2 patient. DN is the single most common cause of ESRD all over world, accounting for 33%. Proteinuria is a key feature of DN and a strong predictor of speed of progression towards end stage renal failure. Aims and Objective :To evaluate and compare the efficacy of Angiotensin converting enzyme inhibitor and Angiotensin receptor blocker in controlling microalbuminuria of Diabetic Nephropathy. OBESRVATIONS AND RESULT 64 cases fulfilling the criteria were choosen and studied. All the cases were randomized into either group (ACE-Is or ARB) and studied at the beginning and at the end of 3 months of treatment after subsequent follow up. There is no worsening/ deterioration of renal function due to treatment with either drugs. reduction in microalbuminuria in both males and females in both Lisinopril and olmesartan group.Discussion The study has shown that both the drugs – Lisinopril and Olmesartan reduce urinary albumin excretion and within the group, the reduction in microalbuminuria is considerable and significant. However, the difference in reduction of microalbuminuria when compared between the two groups is statistically insignificant.