A STUDY OF

P S Shanmugam; Henin Mohan; Shakthi Vignesh

Volume : VI, Issue : IV, April - 2017

A STUDY OF "DEXMEDETOMIDINE FOR ATTENUATING STRESS RESPONSE AFTER LARYNGOSCOPE AND INTUBATION"

P S Shanmugam, Henin Mohan, Shakthi Vignesh

Abstract :

Endotracheal intubation has become one of the frequently performed procedure in the practice of Anesthesia since the time of Introduction of Endotracheal Anesthesia in the last quarter of 19^th century. The process of Laryngoscopy & Intubation are noxious stimuli & therefore constitute period of extreme Haemodynamic stress and associated with intense sympathetic activity mediated by Hypertension & Tachycardia¹.The increase in Pulse rate, Blood pressure are usually unpredictable, variable & transistory.Pharmacological methods like use of β-blockers, Vasodilator, Inhalation agents , Topical & Intravenous Lidocaine, Narcotics, Calcium channel blockers has been tried. For attenuating the stress response,Dexmedetomidine is highly specific and selective α-2 adrenoreceptor agonist with α2:α1 binding selectivity ratio of 1620:1 compare to 220:1 for Clonidine^.Various studies have also found that Dexmedetomidine can decrease the Hemodynamic response to laryngoscopy and Intubation ^{3,4,5,6,7,8,9}.