A STUDY OF CORELATION OF HOMOCYSTEINE LEVELS IN YOUNG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN A TERTIARY CARE CENTRE

Dr. Rajesh.S; Dr. Hrishikesh.V

Volume : VII, Issue : IX, September - 2018

A STUDY OF CORELATION OF HOMOCYSTEINE LEVELS IN YOUNG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN A TERTIARY CARE CENTRE

Dr. Rajesh. S, Dr. Hrishikesh. V

Abstract :

Introduction: Hyperhomocysteinaemia is implicated as a risk factor for several diseases. Homocysteine is influenced by several factors and plasma levels are determined by a combination of acquired and lifestyle factors. Treatment to reduce Homocysteine levels is inexpensive and safe; however, there is still some debate as to whether raised Homocysteine is a cause or effect of disease. Therefore, we decided to study the role of Homocysteine in patients diagnosed with Acute Myocardial Infarction in young and to correlate with other known risk factors.

Material and Methods: This study was conducted as a cross sectional study, wherein written informed consent will be taken prior to the investigation after detailed information given to the participant�s patient party regarding the study on patients aged less than 40 admitted in A. J. Hospital and diagnosed with Acute MI who met a predefined inclusion and exclusion criteria initiated after obtaining clearance from the institutions ethical committee. Homocysteine level estimation done by Fluorescence Polarising Immunoassay. The data was collected in pre-prepared proforma and then transferred to a master chart for analysis. The collected data was analyzed using student�s T test and Chi-Square Test.Statistical Analysis was done using SPSS software version 23.0. A �p� value less than 0.05(p<0.05) is considered significant.

Results:In the study conducted on 60 patients aged less than 40, admitted in A. J. Hospital we found that males were affected more than females in our study. Among the cases (patients with MI) the mean Homocysteine was found to be significantly higher compared to the aged matched controls (patients without MI). After application of statistical analysis using studentsT test it was observed that there was very high significant difference in homocysteine level among 2 groups (p<0.001).

Conclusions: In our study, we intended to study the significance of Homocysteine as a risk factor in patients aged less than 40 diagnosed with Myocardial Infarction. We conclude that elevated Homocysteine levels plays a major role as a risk factor for MI. We recommend that it is efficacious to check Homocysteine levels in patients having strong family history and to treat the same.