A STUDY OF ALTERATION IN LIPID PROFILE IN HYPOTHYROIDISM

Rosy Lekharu; Nikita Hasani; Jayshree Tolani; Ramesh Pradhan

Volume : VII, Issue : II, February - 2018

A STUDY OF ALTERATION IN LIPID PROFILE IN HYPOTHYROIDISM

Rosy Lekharu, Nikita Hasani, Jayshree Tolani, Ramesh Pradhan

Abstract :

Hypothyroidism is associated with an increase in serum concentrations of intermediate-density lipoprotein and low-density lipoprotein (LDL) cholesterol due to a change in metabolic clearance. Hyperlipidaemia may contribute to the higher risk for developing coronary artery disease associated with hypothyroidism. Serum levels of total cholesterol and LDL are often increased in hypothyroid individuals. The LDL particles of hypothyroid patients appear to be more susceptible to oxidation, which potentially makes them more atherogenic. Thyroid hormone replacement therapy may slow the progression of coronary artery disease, because of its beneficial effects on lipids.

For this study, we have selected diagnosed cases of Hypothyroidism undergoing consultation with physician and endocrinologist at the �Gujarat Cancer Society Medical College Hospital and Research Centre, Ahmedabad� belonging to the age group 25-80 years. We have estimated lipid profile in hypothyroid patients, compared the degree alteration in lipid levels as compared to alteration in thyroid hormone levels and tried to assess the risk for cardiovascular disease.

The present study concludes that thyroid dysfunction leads to derangement in the lipid profile. Recognition and treatment of hypothyroidism, can lead to prevention in alteration of lipid profile parameters and thereby prevent the development of atherosclerosis. As TSH is a sensitive parameter for screening thyroid dysfunction, early detection of hypothyroidism and treatment can significantly reduce the incidence of ischaemic heart disease.