A review on chimeric antigen receptors and the current clinical trials on breast cancer therapy

Fasoulakis N Zacharias; Papamanolis Valentinos; Theodora Marianna; Xenitidis Panagiotis; Kontomanolis N Emmanuel

Volume : VII, Issue : VIII, August - 2018

A review on chimeric antigen receptors and the current clinical trials on breast cancer therapy

Fasoulakis N Zacharias, Papamanolis Valentinos, Theodora Marianna, Xenitidis Panagiotis, Kontomanolis N Emmanuel

Abstract :

The appearance of chimeric antigen receptors (CAR) T cells during the past few years has opened a new therapeutic approach for cancer, especially for hematopoietic malignancies, that has already proven to be effective and even considered to be established as the therapy of choice within the next few years.The effectiveness against solid tumors, however, still remains a challenge since many obstacles need to be surpassed, considering demarcation of tumor from normal tissue, homing, as well as tumor penetration and localized-to-tumor acting. The aim of this review is to make a ief report considering CAR T cells and to reveal the current stage-of-research considering the use of CAR T cells against east cancer.