A RETROSPECTIVE STUDY OF BONE MARROW ASPIRATION IN CHRONIC MYELOID LEUKAEMIA (CML) PATIENTS AT TERTIARY CARE HOSPITAL OF JHARKHAND

Dr. Md Raihan; Dr. Sunil Kumar Mahto; Dr. Suraj Sinha

Volume : IX, Issue : VII, July - 2020

A RETROSPECTIVE STUDY OF BONE MARROW ASPIRATION IN CHRONIC MYELOID LEUKAEMIA (CML) PATIENTS AT TERTIARY CARE HOSPITAL OF JHARKHAND

Dr. Md Raihan, Dr. Sunil Kumar Mahto, Dr. Suraj Sinha

Abstract :

Introduction: Chronic myeloid (myelogenous, granulocytic) leukaemia (CML) is a myeloproliferative disorder characterized by proliferation of granulocyte lineage cells and characteristic reciprocal translocation involving chromosomes 9 and 22 leading to BCR-ABL1 fusion gene. It comprises about 20% of all leukaemias. In order to assess the burden of these diseases for public health planning, it is important to study their pattern of epidemiological variables. Aim: A study to determine the clinical and haematological profile in CML patient in Jharkhand, India. Methods: All suspected cases of CML in Peripheral Blood Smear were subjected to bone marrow aspiration, stained with Leishman stain and examined under light microscope. Results: In total of 42 patients, mean age was 36 years, male-female ratio of 2:1 with most of the patients in chronic phase of CML and none in CML-blast crisis. The commonest symptoms of the patients were pain and distension of abdomen (73.80%). Conclusion: Most CML patients in Jharkhand are relatively young (21–40 years). In addition, males were more commonly affected.