A Prospective Study Of Evaluation Of Responses, Toxicities And Survival Of Patients With Conventional External Beam Radiotherapy Versus Intensity Modulated Radiotherapy After Neo Adjuvant Chemotherapy In Locally Advanced Oropharyngeal Cancers.

Ravi Kiran Pothamsetty; Baby Paul Thaliath; Radha Rani Ghosh

Volume : VII, Issue : VII, July - 2018

A Prospective Study Of Evaluation Of Responses, Toxicities And Survival Of Patients With Conventional External Beam Radiotherapy Versus Intensity Modulated Radiotherapy After Neo Adjuvant Chemotherapy In Locally Advanced Oropharyngeal Cancers.

Ravi Kiran Pothamsetty, Baby Paul Thaliath, Radha Rani Ghosh

Abstract :

Head and neck cancer (HNC) is one of the most common cancers in India. The present study analyzed the responses and toxixities comp� conventional radiotherapy [EBRT] and the state of art technology[IMRT]. Complete and partial responders after neoadjuvant chemotherapy, were randomized into Arm A and Arm B and definitive radiation 70Gy/ 35 fractions/7weeks in the form of conventional EBRT in arm A and IMRT in arm B as per institution protocol were delivered. Radiation related toxicities were assessed and documented as per the RTOG criteria. LRF, DFS, and OS at the end of last follow up found to be 10% versus 5%; 70% versus 90%; and 80% versus 95% respectively in arm A versus arm B. The future scope of management of advanced stage oropharyngeal carcinoma lies in judicial utilization of systemic chemotherapy and radiation therapy according to individualized patient centric approach to enhance therapeutic ratio and treatment success.