A prospective, comparative study of Platelet Rich Plasma (PRP) as monotherapy versus combina-tion therapy of PRP with topical minoxidil and systemic finasteride in androgenetic alopecia

Viswanath Vishalakshi; Yadav. S. Jyoti; Patel P Nikita

Volume : VII, Issue : XII, December - 2018

A prospective, comparative study of Platelet Rich Plasma (PRP) as monotherapy versus combina-tion therapy of PRP with topical minoxidil and systemic finasteride in androgenetic alopecia

Viswanath Vishalakshi, Yadav. S. Jyoti, Patel P Nikita

Abstract :

Background: Platelet Rich Plasma (PRP) has emerged as a potential therapy for androgenetic alopecia (AGA).

Aims and Objectives: To Compare safety and efficacy of PRP monotherapy versus combination therapy [PRP+ topical Minoxidil 5% + systemic finasteride(1mg)] in AGA.

Material and Methods: Thirty treatment -naive patients (grade III-VI AGA) were included. Seven PRP sittings were given fortnightly over 3 months. Assessment was based on hair pull test, global photos, patient/ investigator assessment scales. Due to three drop-out patients, final analysis was done on Group A (PRP monotherapy n= 14) and Group B (combination therapy n= 13).

Results: Hair pull test was negative at 12 weeks. Maximum response was seen by 5th session, vertex alopecia showed better response compared to temporal areas. Investigator and patient assessment showed better response in Group B.

Conclusion: PRP showed good efficacy and safety profile. Combination therapy was statistically superior to monotherapy.