A DURATION BASED COMPARATIVE STUDY TO CORRELATE hsCRP WITH MICROALBUMINURIA AMONG DIABETIC OUTPATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN SUBHIMALAYAN REGION.

Dona Acharjya; Swati Bhattacharyya; Ushasi Banerjee

Volume : VII, Issue : XII, December - 2018

A DURATION BASED COMPARATIVE STUDY TO CORRELATE hsCRP WITH MICROALBUMINURIA AMONG DIABETIC OUTPATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN SUBHIMALAYAN REGION.

Dona Acharjya, Swati Bhattacharyya, Ushasi Banerjee

Abstract :

Background: Microalbuminuria in type 2 diabetic patients is speculated to be accompanied by elevated serum high sensitivity C reactive protein (hsCRP). . Establishing a correlation between hsCRP & microalbuminuria relative to duration of diabetes suggests activation of inflammatory pathways in progression of kidney disease .

Materials &Methods: 120 diabetic individuals aged (30-60) yrs ,divided in 3 groups of 40 subjects in each, namely: a) newly diagnosed˂5 years b) 5-10 years after diagnosis and c) ≥10 years after diagnosis were recruited from a tertiary care hospital in sub Himalayan region according to some inclusion and exclusion criteria.

Result: Mean values of hsCRP were 0.04 � 0.005, 0.08 � 0.011, & 0.10 � 0.017 and that of micro albumin were 95.42 � 12.30, 116.79 � 4.87 & 130.56 � 7.65 in group 1,2 ,3 respectively. One way ANOVA with post hoc analysis after Bonferroni correction depicted that both hsCRP & micro albumin increased significantly and statistically with duration of diabetes in all 3 groups along with a very significant correlation between them .

Conclusion:Both serum hsCRP and microalbuminuria increases with period of diabetes.So the increasing trend of these inflammatory markers needs to be noted early and monitored to prevent progression of diabetic nephropathy