A COMPREHENSIVE REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM

Vaishali Chauhan; Harshita Mishra; Kapil Kumar

Volume : VIII, Issue : I, January - 2019

A COMPREHENSIVE REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM

Vaishali Chauhan, Harshita Mishra, Kapil Kumar

Abstract :

The colon is believed to be a suitable site where both local and systemic delivery of drugs could be achieved. Colonic drug delivery has gained increased importance not only for localized treatment of several colonic diseases, mainly inflammatory bowel disease (crohn�s disease, ulcerative colitis) and colon cancer, but also as a potential site for the systemic delivery of therapeutic proteins and peptides. The site specific delivery of drugs (Drug targeting) to lower parts of GIT improve the efficacy of drugs by concentrating the drug molecules at the site of action and minimize systemic side effects and drug instability issues. Consequently, various strategies have been developed for CTDDS (Colon targeted Drug Delivery System), which includes prodrugs, pH and time dependent systems, Bacterial enzyme dependent colonic DDS, pressure controlled colonic delivery and osmotic controlled drug delivery.