A COMPARISON OF RECOVERY PROFILE AND POSTOPERATIVE HEMODYNAMICS BETWEEN DEXMEDETOMIDINE AND ESMOLOL FOLLOWING THEIR INTRAOPERATIVE ADMINISTRATION

Selvi Annie Geeta; Dr Muthushenbagam

Volume : VI, Issue : VII, July - 2017

A COMPARISON OF RECOVERY PROFILE AND POSTOPERATIVE HEMODYNAMICS BETWEEN DEXMEDETOMIDINE AND ESMOLOL FOLLOWING THEIR INTRAOPERATIVE ADMINISTRATION

Selvi Annie Geeta, Dr Muthushenbagam

Abstract :

Background and goals of study: Dexmedetomidine and Esmolol are used intraoperatively for many indications. This study compares the recovery profile and postoperative hemodynamics, along with the postoperative analgesic requirement following intraoperative usage of Dexmedetomidine and Esmolol as hypotensive agents during General Anesthesia

Methods: We included 60 ASA l &ll patients in the study. Patients were randomly allocated to two groups. Group A (n= 30) : Patients receiving Dexmedetomidine. Group B (n= 30) : Patients receiving Esmolol. In Group A, patients received loading dose of 1 μg/kg Dexmedetomidine diluted in 10 ml 0.9% saline infused over 10 min, before induction of anesthesia, followed by continuous infusion of 0.4 – 0.8 μg/kg/h. In Group B, patients received Esmolol as a loading dose 1 mg/kg, infused over 1 min, before induction of anesthesia, followed by continuous infusion of 0.4-0.8 mg/kg/h. The recovery profile was assessed using Modified Aldrete Score. Postoperative hemodynamics, sedation score and analgesic request are compared.

Results: The emergence time and the time to attain modified Aldrete score ≥9 was significantly longer in Dexmedetomidine group. The pulse rates and blood pressures were significantly higher in the Esmolol group both during the immediate postoperative period as well as in the PACU. The sedation score in the PACU was higher in the Dexmedetomidine group. The first analgesic request was significantly earlier in the Esmolol group.

Conclusion: Dexmedetomidine is associated with delayed recovery and higher sedation scores, but better hemodynamics and analgesia during the postoperative period, when compared with Esmolol.