A Comparative study to compare the effect of Volume guarantee ventilation and Pressure limited ventilation on required duration of ventilation in preterm infants

Dr. Amit Kumar; Dr. Mani Kant; Dr. Sweta; Dr Rajan V. Joshi; Dr. Shilpa U. Kalane

Volume : IX, Issue : V, May - 2020

A Comparative study to compare the effect of Volume guarantee ventilation and Pressure limited ventilation on required duration of ventilation in preterm infants

Dr. Amit Kumar, Dr. Mani Kant, Dr. Sweta, Dr Rajan V. Joshi, Dr. Shilpa U. Kalane

Abstract :

Background: Volume guaranteed (VG) is a novel mode, best described as a dual loop synchronized modality that ventilates with time cycled pressure limited ventilation. It provides automatic adjustment of the peak inspiratory pressure for ensuring a minimum set tidal volume. There are limited data about the effects of VG ventilation on required duration of ventilation and short term neonatal outcomes in preterm infants with respiratory distress syndrome (RDS). Objective: The objective of this study was to evaluate the effect of VG ventilation on required duration of ventilation. Methods: This prospective randomized comparative study was conducted at level III b NICU of Deenanath Mangeshkar Hospital & Research Center, Pune between May2016 to April 2017. Forty six preterm infants who required mechanical ventilation were randomly divided into 2 groups [SIPPV group (n=23) and SIPPV + VG group (n=23)]. Required duration of mechanical ventilation was recorded. Post extubation CPAP duration and duration of oxygen requirement were also recorded. Results: There were no significant differences between two groups in terms of demographic features. Infants ventilated with VG mode had shorter duration of ventilation (statistically not significant). Extubation failure was observed less frequently with SIPPV + VG mode of ventilation. Post extubation duration of CPAP requirement and duration of oxygen requirement were significantly less (p-value <0.05) in infants ventilated with VG mode. Conclusion: In conclusion, in our study VG ventilation significantly reduced duration of CPAP and oxygen requirement in preterm infants. A trend in reduction in required duration of ventilation was also observed with VG mode of ventilation. This data favours the use of VG ventilation in respiratory support of premature infants.