A comparative Study of Omeprazole vs Ranitidine in Duodenal ulcer in PMCH, Patna

AMAN KUMAR; RAVINDRA KUMAR; Md. ADIL; PANKAJ KUMAR

Volume : VIII, Issue : II, February - 2019

A comparative Study of Omeprazole vs Ranitidine in Duodenal ulcer in PMCH, Patna

Aman Kumar, Ravindra Kumar, Md. Adil, Pankaj Kumar

Abstract :

Duodenal ulcer is most common disease worldwide. The mainstay of treatment of duodenal ulcer is suppression of acid secretion is thought to reduce the risk of ulcer. The treatment of acid peptic disorder (Duodenal ulcer being the most commonest ) has passed through 2 major advances with advent of (1) H2 receptor antagonists by Sir james black (1972), (2) Omeprazole , the first gastric proton pump inhibitor which blocks the final common pathway (H+/K+ ATPase- proton pump ) of acid secretion, irrespective of the stimulus on gastric parietal cells. In this series we studied 102 patients with use of ranitidine and omeprazole in PMCH,Patna and found that Omeprazole is a rational anti ulcer drug and is drug of 1st choice for refractory uncomplicated duodenal ulcer and ideal for duodenal ulcer in smokers and long term NSAID users