A COMPARATIVE STUDY OF INTRATHECAL DEXMEDETOMIDINE WITH INTRATHECAL MAGNESIUM SULFATE USED AS ADJUVANTS TO BUPIVACAINE

Dr. Seema Regar; Dr. Manohar Lal Kanwaria

Volume : VI, Issue : IV, April - 2017

A COMPARATIVE STUDY OF INTRATHECAL DEXMEDETOMIDINE WITH INTRATHECAL MAGNESIUM SULFATE USED AS ADJUVANTS TO BUPIVACAINE

Dr. Seema Regar, Dr. Manohar Lal Kanwaria

Abstract :

BACKGROUND: This prospective double blind, randomized study was conducted to compare the Dexmedetomidine with magnesium sulfate added to hyperbaric bupivacaine in Spinal Anesthesia. Materials and Methods: A total of 50 patients ASA grade I & II were randomly assigned into one of the two groups, containing 25 patients each. Group A (n=25) consist of patients receiving 3 ml of 0.5% hyperbaric bupivacaine and 0.1 ml (10mcg) Dexmedetomidine. Group B (n=25) consist of patients receiving 3 ml of 0.5% hyperbaric bupivacaine + 0.1 ml (50 mg) Mg.sulfate. RESULTS: The mean time of onset of sensory block in group A was 2.28+1.173 and in group B was 7.04+3.23 min with p value <.001. The mean sensory Block time to reach max in group A was 5.60+2.915 and in group B was 14.32+4.67. The mean time of the onset of motor block in Group A was 4.48+1.851 and in group B was 10.76+5.027 that was significantly higher in group B(P value <.001) means motor onset was fast in group A. A mean Duration of motor block was 312.4+116.072 in group A and in group B it was 226.60+84.960. The duration of motor block was found to be significantly longer in Group A compared to Group B (p<0.001). Total duration of analgesia was significantly higer in group A (393.40+116.072) as compare to group B (304.40+80.885). (Pvalue <.001). Conclusion: In present study we concluded that 10 micrograms of dexmedetomidine as adjuvant to spinal bupivacaine in surgical procedures of long duration has earlier onset and prolonged duration of sensory and motor block without associated significant hemodynamic alteration and provides excellent quality of postoperative analgesia. Intrathecal Mg also prolongs the duration of spinal analgesia, but this is less than intrathecal dexmedetomidine and is with a delayed onset.