A Comparative Study of Intranasal Dexmedetomidine and Intranasal Midazolam as Premedication in Children Undergoing Short Surgical Procedures

Dr. Rahul Fernandez; Dr. Moses Charles Dsouza; Dr.Surbhi Gupta; Dr. Sumithra Selvam

Volume : VII, Issue : XII, December - 2018

A Comparative Study of Intranasal Dexmedetomidine and Intranasal Midazolam as Premedication in Children Undergoing Short Surgical Procedures

Dr. Rahul Fernandez, Dr. Moses Charles Dsouza, Dr. Surbhi Gupta, Dr. Sumithra Selvam

Abstract :

Introduction : Anaesthetizing children for surgery can be challenging due to parental separation anxiety and an unfamiliar OT environment. Various drugs have been tried for pre- medication to alleviate this anxiety and facilitate induction of anesthesia. We compared Intranasal Dexmedetomidine and Intranasal midazolam for premedication in children undergoing short surgical procedures.

Materials and Methods: 104, ASA grade I and II children between 2-10 years, scheduled for elective short surgical procedures were randomly allocated to receive intranasal Dexmedetomidine (1�g/kg) (Group D) or intranasal Midazolam (0.2mg/kg) (Group M) . The Parental Separation Anxiety Score, MOAA/S scores ,Mask Acceptance Score and 24 hr vitals were assessed

Results: The parental separation and MOAA/S scores attained with intranasal Dexmedetomidine premedication were found to be superior to intranasal Midazolam (p<0.0001). The mask acceptance was better among children premedicated with intranasal Dexmedetomidine than with Midazolam . There was a statistically significant decline in the heart rate in the group D compared to group M after premedication

Conclusion: Children premedicated with intranasal Dexmedetomidine separated much more easily from parents with a better degree of sedation and better mask acceptance compared to those premedicated with intranasal Midazolam.