A comparative study of epidural Ropivacaine 0.75% alone versus epidural Ropivacaine 0.75% with preservative free midazolam in vaginal hysterectomies

Volume : VII, Issue : VI, June - 2018

Dr. Vagdandapu Vijayalakshmi, Dr. Gowthami Priya Ojili

A randomized prospective comparative double blind study was conducted on ASA I and II patients of female sex,

aged between 30-60 years posted for vaginal hysterectomies. They are divided into two groups of 30 each.

Aims and objectives: To Assess and compare the efficacy of epidural Ropivacaine 0.75% Vs epidural Ropivacaine 0.75% and preservative

free Midazolam in terms of onset, duration of sensory and motor blockade, duration of analgesia and to evaluate the incidence of adverse

effects and complications associated with vaginal hysterectomies.

After preloading, under aseptic precautions epidural catheter was placed in L3-4 space. In Group A – 18 ml of 0.75% Ropivacaine + 2ml

Normal saline injected into epidural space. In Group B 18ml of 0.75% Ropivacaine + 2ml preservative free Midazolam (2mg) injected into

epidural space.

The various parameters studied and the results and observations of the two groups were compared. With regard to age, height, the mean

sensory level achieved, duration of motor blockade, respiratory rate and oxygen saturation, the difference is considered to be statistically

not signi􀃶cant. There was signi􀃶cant difference with regard to duration of analgesia and sedation ( Group A 304.33�25.15 min, Group B

318.00�25.78 with P value 0.0421 ). It can be concluded that addition of preservative free Midazolam 2mg to 18 ml of 0.75% Ropivacaine by

epidural route, causes de􀃶nite prolongation of analgesia together with optimum sedation and without signi􀃶cant side effects.