A COMPARATIVE STUDY BETWEEN BUPIVACAINE AND BUPIVACAINE CLONIDINE COMBINATION IN SPINAL ANAESTHESIA IN LOWER LIMB SURGERIES

Dr Manisha Thakkar; Dr Manisha Kapdi

Volume : VI, Issue : I, January - 2017

A COMPARATIVE STUDY BETWEEN BUPIVACAINE AND BUPIVACAINE CLONIDINE COMBINATION IN SPINAL ANAESTHESIA IN LOWER LIMB SURGERIES

Dr Manisha Thakkar, Dr Manisha Kapdi

Abstract :

Background and aims: Intrathecal clonidine prolongs sensory and motor effect of intrathecal bupivacaine for spinal anaesthesia. Methods: A randomised controlled trial of 60 patients (30 in each group) was conducted in patients posted for lower limb surgeries under spinal anaesthesia. In group A 0.5% heavy bupivacaine 3 ml (15 mg) + NS (0.3 ml) and in Group-B 0.5% heavy bupivacaine 3 ml (15 mg) + preservative free clonidine 0.3 ml (45 μg) given intrathecally. Time of onset of sensory and motor blockage, per and postoperative hemodynamics, time of regression of sensory and motor blockage and first requirement of rescue postoperative analgesic were noted. Results: In randomised controlled study time to onset of sensory and motor block was rapid in group A than group B(P<0.001). Total duration of sensory and motor blockade was higher in group B patients as compare to group A(P<0.001). Time to first rescue analgesic was prolonged in group B patients (392 + 34.21 minutes) as compare to group A patients (251 + 24.04 minutes). Conclusion: Clonidine 45�g seems to be attractive, alternative as adjuvant to intrathecal hyperbaric bupivacaine heavy(0.5%) which markedly prolongs duration of sensory and motor blockage, provides excellent quality of postoperative analgesia with minimum hemodynamic changes and adverse reaction.